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WASHINGTON Cheap Curtis Riley Jersey , May 26 (Xinhua) -- Researchers from the United States and the Netherlands said Tuesday they have identified Ebola 's Achilles' heel that could be targeted to completely block the deadly virus's infection.


The researchers reported in the online U.S. journal mBio that Ebola can't infect mice unless it first attaches to a host protein called Niemann-Pick C1 (NPC1).


"Our study reveals NPC1 to be an Achilles' heel for Ebola virus infection," co-study leader Kartik Chandran, associate professor of the Albert Einstein College of Medicine of Yeshiva University Cheap Jon Halapio Jersey , said in a statement.


"Mice lacking both copies of the NPC1 gene, and therefore devoid of the NPC1 protein, were completely resistant to infection. "


Previous in vitro studies have demonstrated that Ebola enters host cells by binding directly to NPC1 Cheap Landon Collins Jersey , and that blocking the ability of the virus to engage NPC1 prevents Ebola infection.


To test whether this was also true in vivo, the team exposed three types of mice to Ebola: wild-type or normal mice, "knockout mice" that were genetically engineered to be completely deficient in NPC1 Cheap Sterling Shepard Jersey , and "carrier mice" engineered to have both a normal and a mutant NPC1 allele.


While the wild type mice succumbed to the infection, the " knockout mice" were entirely free of virus replication and completely protected against the disease, they found.


"Carrier mice" initially had high levels of Ebola viremia Cheap Dalvin Tomlinson Jersey , but the levels quickly decreased as the host immune response effectively cleared the virus.


"The underlying story of an Ebola infection is that your immune system and the virus are in a race," said co-study leader John Dye, branch chief of viral immunology at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).


"If you can do anything to control the amount of virus that is in the system Cheap Evan Engram Jersey , keep it below a certain threshold, your immune system in many cases will win that race."


NPC1 helps transport cholesterol within the cell. People lacking NPC1 due to genetic mutations develop a fatal neurodegenerative disorder called Niemann-Pick disease, which is sometimes referred to as childhood type of Alzheimer's disease.


Even though such a treatment in humans would also block the cholesterol transport pathway Cheap B.J. Hill Jersey , "we think patients would be able to tolerate the treatment, which would be needed for only a short time," said Andrew Herbert Cheap Will Hernandez Jersey , senior research scientist in the viral immunology branch at the USAMRIID, and co-first author of the study.


The team hoped that future research in humans could lead to the development of antiviral drugs that can effectively target NPC1 and prevent infection by Ebola and other highly virulent filoviruses, which also require NPC1 as a receptor.


Currently Cheap Odell Beckham Jr Jersey , there are no approved treatments for Ebola, and all of the therapies in the drug pipeline focus on attacking the virus. Targeting NPC1 is the first host-based therapeutic approach.




WARSAW, June 19 (Xinhua) -- Chinese President Xi Jinping arrived in Poland Sunday on the second stop of his three-nation Eurasia tour aimed at cementing bilateral ties and strengthening China's relations with Europe.


It is the first state visit by a Chinese head of state to Poland in 12 years. Before visiting Poland, Xi visited Serbia from June 17 to June 19.


The visits, which came on the heels of Xi's visit to the Czech Republic in March, demonstrate the great importance China attaches to its ties with Central and Eastern Europe (CEE) and with the European Union (EU), said Liu Zuokui, a scholar with the Institute of European Studies, Chinese Academy of Social Sciences.


During his stay in Warsaw, Xi is scheduled to hold talks with Polish President Andrzej Duda on enhancement of bilateral ties.


He will also meet with Polish Prime Minister Beata Szydlo, and attend a luncheon hosted by Polish parliamentary leaders. The two sides are expected to sign agreements in areas such as finance, civil aviation, science and technology, and education.


Poland established diplomatic relations with China in October 1949, making it one of the first countries to forge official diplomatic ties with the People's Republic of China. Since the two countries lifted their bilateral ties to a strategic partnership in 2011, their relations have been on a "fast track" with deepening political trust and widening cooperation in economy and trade, tourism and education.


With bilateral trade reaching 17.1 billion U.S. dollars in 2015, Poland is China's largest trading partner in the CEE region, while China is Poland's largest trading partner in Asia. More than 60,000 Chinese tourists travelled to Poland last year, up from 7,700 in 2004. Five Confucius Institutes have been established in the country.


Xi's visit is expected to help further align China's Belt and Road Initiative with Poland's development plans and promote Poland's role as an "engine" to boost China-CEE cooperation.


During a state visit to China by Duda in November last year, the two countries inked a memorandum of understanding on jointly promoting the Belt and Road Initiative.


Proposed by Xi in 2013, the Belt and Road Initiative refers to the Silk Road Economic Belt that links China with Europe through Central and Western Asia by inland routes, and the 21st-Century Maritime Silk Road connecting China with Southeast Asia, Africa and Europe by sea routes. It is a development initiative that focuses on inter-connectivity and cooperation among countries primarily in Eurasia.


Poland sits in the center of Europe, and many of the China-Europe freight trains pass through the country. Chinese experts believe that Poland has a potentially great role to play as a logistics hub between China and the CEE region, as well as between China and Europe.


After visiting Poland, Xi is to travel to Uzbekistan for a state visit and attend a summit of the Shanghai. Cheap Nike Vapormax Black Cheap Nike Vapormax Pink Cheap Old Skool Mens Cheap Old Skool Leather Cheap Old Skool Red Cheap Old Skool Suede Cheap Old Skool Shoes Cheap Old Skool Grey Wholesale Jerseys China Free Shipping Wholesale Adidas NHL Jerseys


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